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First Womb Transplant in UK Hailed as Massive Success

Patient ‘incredibly happy’ after operation that could allow dozens of infertile women a year to have babies

BBC 23 AUG 2023

https://e3.365dm.com/23/08/768x432/s...20230822234315

Isabel Quigora and Richard Smith in the operating theatre

Surgeons have performed the first womb transplant on a woman in the UK, opening up the possibility for dozens of infertile women to have babies every year. The woman’s sister was the living donor of the womb.

The 34-year-old was “incredibly happy” and “over the moon” with the success of the nine-hour operation, according to the medical team behind the pioneering procedure. She now plans to have two children using IVF.

The married woman was born with a rare condition, meaning her original womb was underdeveloped. She received a donor womb from her 40-year-old sister, who already had two children of her own.

More than 90 womb transplants have been carried out internationally, including in Sweden, the US, Saudi Arabia, Turkey, China, Czech Republic, Brazil, Germany, Serbia and India, with most involving a living donor. About 50 babies have been born as a result.

The co-lead surgeon Isabel Quiroga, a consultant surgeon at the Oxford Transplant Centre, part of Oxford University hospitals, said she was “thrilled” and “extremely proud” the surgery had been a success.

The patient is “incredibly happy”, she said, adding: “She was absolutely over the moon, very happy and is hoping that she can go on to have not one but two babies. Her womb is functioning perfectly and we are monitoring her progress very closely.”

A second UK womb transplant on another woman is scheduled to take place this autumn, with more patients in the preparation stages. Surgeons have approval for 10 operations involving brain-dead donors plus five using a living donor.

The recipient, who lives in England and asked not to be named, received her sister’s uterus in an operation in February at Churchill hospital in Oxford. It took nine hours and 20 minutes and she was well enough to leave hospital after 10 days.

The co-lead surgeon Prof Richard Smith, the clinical lead at the charity Womb Transplant UK and a consultant gynaecological surgeon at Imperial College London, said the operation had been a “massive success”.

“It was incredible,” he said. “I think it was probably the most stressful week in my surgical career but also unbelievably positive. The donor and recipient are over the moon, just over the moon.

“I feel emotional about it all. The first consultation with the recipient post-op, we were all almost in tears.

“I’m just really happy that we’ve got a donor who is completely back to normal after her big op and the recipient is, after her big op, doing really well on her immunosuppressive therapy and looking forward to hopefully having a baby.”