Messi Is Unstoppable, Unless...
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You focus on stopping Barcelona, and not him alone.
In the first half, Dutt sent out his players with clear instructions to nullify Messi at all costs. You could tell because every time he touched the ball, he was instantly surrounded by at least two or three Leverkusen players.
If Leverkusen's goal was to stop Messi from scoring, they succeeded. Unfortunately, that didn't matter too much, because as Real Madrid have found out too well, if the focus is on stopping Messi, he'll find an unmarked man to do the scoring for him.
This happened with Pedro in the Copa del Rey second leg against Real Madrid, and it happened with Alexis Sanchez today in the first half.
People underrate Messi's passing abilities, but there's a reason he has 24 assists this season and 28 last season. In addition to being able to create space for his teammates, his ability to pick out his passing is impeccable.
So trying to stop Barcelona by focusing on Messi likely means failure. He'll simply pick out a teammate and let him score instead.
The only way to take points off Barcelona is by preventing Barcelona from playing their game and consistently attacking their defense, which is generally their weak-point since it seems Guardiola is never able to have his entire first-choice defense fit and playing on a regular basis.
Osasuna and Getafe has succeeded at doing this, and they are the models to follow for other underdogs attempting to beat Barcelona in any competition.