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Old 08-07-14, 17:05   #1
 
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Movies UK Scientists Discover Wonder Drug-Turning Point in Alzheimers’ Fight

Blood Test Could Predict Alzheimer's Disease

BBC News, 8 July 2014




Doctors could one day have a blood test at their disposal that allows them to predict
which patients may be at risk of developing Alzheimer's disease, researchers have said.



A team of scientists led by King's College London and British firm Proteome Sciences carried out examinations of the blood of 452 healthy people, 220 with mild cognitive impairment and 476 with Alzheimer's disease.
Using ten proteins as biomarkers, they were able to tell with an accuracy level of 87 per cent which of those with mild impairment would go on to show signs on Alzheimer's within a year.

At present, the development of drugs to treat the degenerative disease has continued to stall because trials are carried out on people who are already showing symptoms. Since this can happen up to ten years after the onset of Alzheimer's, many of these patients have already experienced too much damage to the structure of their brains.

Scientists therefore want to treat people much earlier - but they need a prediction test to do so and it is hoped this new discovery will provide the missing link.
'We want to be able to identify people to enter clinical trials earlier than they currently do and that's really what we've been aiming at,' lead researcher Professor Simon Lovestone from the University of Oxford told BBC News.

The research is published this month in the journal Alzheimer's & Dementia and further studies will now be carried out to improve trials for potential new dementia drugs.

However, it will take several years and much larger trials before the team can be sure the blood test is safe for widespread use. The next studies will look into boosting accuracy still further, as well as reducing the possibility of misdiagnosis and addressing the issue of depression among people who have been told they may develop the disease.
Nevertheless, Alzheimer's Research UK called the breakthrough a 'technical tour de force'.

It comes just a few weeks after UK Prime Minister David Cameron called dementia one of the 'greatest enemies of humanity' and urged researchers and healthcare experts to get behind a 'big push' aimed at beating it within the next few years.
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Old 12-03-15, 18:25   #2
 
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New Zealand Australian Scientists Major Breakthrough to Treat Alzheimers

Hope for Alzheimer's sufferers with Scientists Developing a Treatment to RESTORE Memory Loss

  • University of Queensland scientists have made the medical breakthrough
  • 'Cheap' and 'mobile' ultrasound device that can be used for treatment
  • Drug-free treatment breaks down the plaques that cause memory loss
  • Will be particularly helpful to suffers in the early stages of the illness
  • Tested on mice who were put through mazes and had to remember objects
Daily Mail Australia, 12 March 2015


Australian scientists have made a major breakthrough in treating Alzheimer's with a new drug-free method that can restore memory loss.


Researchers at the University of Queensland's Brain Institute hope to be able to trial their new 'cheap and mobile' ultrasound device within two years on humans.
The treatment attacks the neurotoxic amyloid plaques that cause memory loss and cognitive failure with ultrasound waves.

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Researchers at the University of Queensland's Brain Institute hope to be able to trial their new 'cheap and mobile' ultrasound device within two years on humans.





Research director Professor Jürgen Götz hopes the new method will revolutionise Alzheimer's treatment by restoring memory for sufferers.



'We're extremely excited by this innovation of treating Alzheimer's without using drug therapeutics,' Professor Götz said, according to The Australian.

'The word 'breakthrough' is often misused, but in this case I think this really does fundamentally change our understanding of how to treat this disease, and I foresee a great future for this approach.'

The mobile device could be used by patients in their own homes several times a year,eliminating the need for expensive drug treatment that costs up to $250,000, Prof Götz said.

'With an ageing population placing an increasing burden on the health system, an important factor is cost, and other potential drug treatments using antibodies will be expensive,' he said.





The mobile device could be used by patients in their own homes several times a year,eliminating the need for expensive drug treatment that costs up to $250,000, Prof Götz said.



'In contrast, this method uses relatively inexpensive ultrasound and microbubble technology which is non-invasive and appears highly effective.'

Almost two thirds of all dementia patients in Australia suffer from Alzheimer's, which accounts for almost 250,000 people.
The total number of dementia cases in Australia is expected to rise to 900,000 by 2050.

Findings of the research, 'Scanning ultrasound efficiently removes amyloid-β and restores memory in an Alzheimer's model', are published in the journal.


An Alzheimer's Society video: What is Alzheimer's Disease?


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Old 15-11-21, 15:30   #3
 
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Movies Breakthrough Cure on Alzheimers- Jab Found to Restore Memory

Breakthrough on Alzheimers Cure as Jab Found to Restore Memory – for Just £15 a Dose

Experiments on mice found the new vaccine destroys rogue proteins in the brain and, in doing so, restores memory - for just £15 a dose


Daily Mirror 15 NOV 2021.






MRI image of a healthy brain (L) and an Alzheimer's brain (R)
The pioneering therapy could revolutionise treatment


A vaccine that could reverse and even prevent Alzheimer’s – for just £15 a dose.


Experiments on mice found the vaccine destroys rogue proteins in the brain and, in doing so, restores memory.

The pioneering therapy could revolutionise treatment, according to British and German scientists.

Clinical trials on the technique, which targets soluble and highly toxic *fragments of amyloid beta that clump into plaques, could begin in two years.

Professor Thomas Bayer, of Gottingen University in Germany, who is co-author of the study, said: “In clinical trials, none of the potential treatments have shown much success in terms of reducing Alzheimer’s symptoms. Some have even shown negative side effects. So we decided on a different approach.

“We identified an antibody in mice that would neutralise the truncated forms of soluble amyloid beta, butwould not bind either to normal forms of the protein or to the plaques.”

The team next adapted the antibody, called TAP01, so our immune system would not recognise it as foreign. To their surprise, the protein folded back on itself.

In tests, both the antibody and the engineered vaccine repaired the brain’s neuron function and increased glucose metabolism in the brain, bringing back the memories of the mice.





Doctor viewing CT scan result of brain on digital tablet for abnormalities
The results have been described as "transformative"






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Old 05-05-23, 03:52   #4
 
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Movies re: UK Scientists Discover Wonder Drug-Turning Point in Alzheimers’ Fight

Best Ever Alzheimers’ Drug Can Slow Disease by a Third

We could be entering the era of Alzheimer's treatments, after the second drug in under a year has been shown to slow the disease.


BBC News 5 MAY 2023





Dr Cath Mummery, the clinical lead for the cognitive-disorders clinic in the UK


Experts said we were now "on the cusp" of drugs being available, something that had recently seemed "impossible".

The company Eli Lilly has reported its drug - donanemab - slows the pace of Alzheimer's by about a third.

However two volunteers, and possibly a third, died as a result of dangerous swelling in the brain.



Sticky Gunk


Donanemab works in the same way as lecanemab, which created headlines around the world when it was the proven to slow the disease.

Both are antibodies like those the body makes to attack viruses. But these are engineered to clear a sticky gunk from the brain, called beta amyloid.

Amyloid builds up in the spaces between brain cells, forming distinctive plaques that are one of the hallmarks of Alzheimer's.

"The decades-long battle to find treatments that change Alzheimer's disease is changing," Dr Cath Mummery, the clinical lead for the cognitive-disorders clinic at the UK's National Hospital for Neurology and Neurosurgery, said.

"We are now entering the time of disease modification, where we might realistically hope to treat and maintain someone with Alzheimer's disease, with long-term disease management rather than palliative and supportive care."


The full details of Eli Lilly's trial have yet to be published - but it has revealed the key findings:

1,734 people in the earliest stages of Alzheimer's took part


Donanemab was given as a monthly infusion until the distinctive plaques in the brain were gone


The pace of the disease was slowed by about 29% overall - and by 35% in a set of patients researchers thought more likely to respond


Those given the drug also retained more of their day-to-day lives such as being able to discuss current events, drive or pursue hobbies

However, brain swelling was a common side-effect in up to a third of patients.


It was mostly mild or asymptomatic despite being detected on brain scans - but 1.6% developed dangerous brain swelling, with two deaths directly attributed to it and a third volunteer dying after such a case.

"We are encouraged by the potential clinical benefits that donanemab may provide, although like many effective treatments for debilitating and fatal diseases, there are associated risks that may be serious and life-threatening," Eli Lilly group vice-president of neuroscience research and development Dr Mark Mintun said.

The company said it would begin the process of having its drug approved for use in hospitals in the next few months.

Dr Liz Coulthard, from the University of Bristol, said there were "significant side-effects" and a lack of long-term data but the drug could "help people live well with Alzheimer's for longer".


'Thought impossible'


Having two drugs slow the disease by targeting amyloid in the brain has also convinced scientists they are on the right track after decades of misery and failure.

"This should dispel any lingering doubts about this approach," Prof John Hardy, from the UK Dementia Research Institute, whose work led to the idea of targeting amyloid, 30 years ago, said. "Having two drugs is great for competition."

Dr Susan Kolhaas, from Alzheimer's Research UK, said: "We're now on the cusp of a first generation of treatments for Alzheimer's disease, something that many thought impossible only a decade ago."


However, these drugs appear to work in only the earliest stages of the disease - before the brain is too damaged.

And if they are approved in the UK, it would still take a revolution in how the disease is diagnosed to make a difference.


Only 1-2% of people have either brain scans or a spinal-fluid analysis to determine whether they actually have Alzheimer's or another form of dementia against which the drugs would be useless.

And the NHS would have to decide whether it could afford them. Lecanemab costs more than £21,000 per person per year.





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Old 18-07-23, 04:05   #5
 
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Movies Re: UK Scientists Discover Wonder Drug-Turning Point in Alzheimers’ Fight

Alzheimers' Wonder Drug Can Slow Disease Progression by 60pc

New Drug Brings Hope to End Alzheimers. Drug Donanemab Seen as Turning Point in Dementia Fight


BBC NEWS 18 JUL 2023






A new drug, donanemab, is being hailed as a turning point in the fight against Alzheimer's, after a global trial confirms it slows cognitive decline.

The antibody medicine helps in the early stages of the disease by clearing a protein that builds up in the brains of people with this type of dementia.

Although not a cure, charities say the results in the journal JAMA mark a new era where Alzheimer's can be treated.



The UK's drugs watchdog has started assessing it for possible NHS use.

The drug works in Alzheimer's disease, not in other types of dementia, such as vascular dementia.

In the trials, it appears to have slowed the pace of the disease by about a third, allowing people to retain more of their day-to-day lives and tasks, such as making meals and enjoying a hobby.

Mike Colley, who is 80, is one of only a few dozen patients in the UK to take part in the global trial. He and his family spoke exclusively with the BBC.

Mike gets an infusion each month at a clinic in London and says he is "one of the luckiest people you'll ever meet".




Mike Colley (L) with his son Mark




Mike and his family noticed he was having problems with memory and decision-making, not long before he started on the trial.

His son, Mark, said it was very hard to watch at the beginning: "Seeing him struggle with processing information and solving problems was very hard. But I think the decline is reaching a plateau now."

Mike, who is from Kent, said: "I feel more confident every day."

Donanemab, made by Eli Lilly, works in the same way as lecanemab - developed by companies Eisai and Biogen - which created headlines around the world when it was proven to slow the disease.

Although extremely promising, these drugs are not risk-free treatments.


Brain swelling was a common side-effect in up to a third of patients in the donanemab trial. For most, this resolved without causing symptoms. However, two volunteers, and possibly a third, died as a result of dangerous swelling in the brain.

Another antibody Alzheimer's drug, called aducanumab, was recently rejected by European regulators over safety concerns and a lack of evidence that it was effective enough for patients.


What is dementia and what can be done about it?


In the donanemab trial, researchers examined 1,736 people aged 60 to 85 with early-stage Alzheimer's.

Half of them received a monthly infusion of the treatment and the other half were given a dummy drug, also known as a placebo, over 18 months.


The findings show:

The drug seems to have a meaningful benefit, at least for some patients


Those who had earlier disease and less brain amyloid at baseline derived greater benefit, in terms of clearance seen on brain scans


Those given the drug also retained more of their day-to-day lives such as being able to discuss current events, answer the phone or pursue hobbies


The pace of the disease, judged by what people could still do day-to-day, was slowed by about 20-30% overall - and by 30-40% in a set of patients who researchers thought more likely to respond


There were significant side-effects and patients will need to be aware of risks of treatment


Half of patients on donanemab were able to stop the treatment after a year, because it had cleared sufficient brain deposits


Amyloid is just one part of the complex picture of Alzheimer's, and it is unclear if the treatment will continue to make more difference over a longer period, experts caution.















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