CC cleaner is great for cleaning the system. Here's another tip for once it is clean. Go get Sandboxie
http://www.sandboxie.com/index.php?DownloadSandboxie
It's free. Once you have it installed, run your browser in the sandboxed mode. Any downloads you get in, it will allow you to place anywhere on your computer, after you've oked the transfer. Everything else is ran in sandbox mode. That means if you get malware, it doesn't get installed on your computer and when you close the browser, the malware is no longer.